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Asthma a Significant Risk Factor for Complications In Children With H1N1 OTTAWA, Ontario -- November 20, 2009 -- A new study on paediatric influenza A(H1N1) admissions has found that asthma is a significant risk factor for severe disease in children with H1N1 compared with the seasonal flu. The study, led by researchers from The Hospital for Sick Children (SickKids) in Toronto, Ontario, is published online today in Canadian Medical Association Journal. Researchers analysed the charts of 58 children admitted to SickKids between May 8 and July 22, 2009 and compared them to 200 children admitted with seasonal influenza between 2004 and 2009. Every year, the hospital admits about 40 children, aged less than 18 years, during the influenza season. Of the children admitted with H1N1, 22% had asthma compared with 6% of those admitted with seasonal influenza. Asthma was determined as a prior diagnosis of asthma or reactive airways disease, or a history of wheeze with the use of inhalers. Almost half of all admissions to the intensive care unit for H1N1 were children with asthma. The children with H1N1 were older than those admitted for seasonal influenza, with significantly more aged over 5 years. Many children (84%) presented with fever and cough, with or without additional symptoms and 37% had gastrointestinal symptoms such as vomiting and/or diarrhoea. The median duration of hospital stay for both H1N1 and seasonal influenza was 4 days. “The most striking finding in our study was the high prevalence of asthma among children admitted with H1N1 influenza compared with those admitted in previous influenza seasons,” the authors wrote. None of the children admitted with H1N1 died compared with 1 death (0.4%) over 5 years in those admitted for seasonal influenza. The authors found that severity of asthma was broad and that children with mild asthma were also at risk. They concluded that children with mild asthma should be vaccinated for H1N1 and considered for antiviral therapy. SOURCE: Canadian Medical Association Journal E-mail this page to a friend or colleague! To print, use this version