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| |  Verapamil Injection Eases Pain of Peyronie’s Disease: Presented at ESSM By Jill Stein LYON, France -- November 17, 2009 -- Intralesional injection of verapamil in patients with Peyronie’s plaque lessens the pain in about half of cases, but usually does not improve penile curvature, investigators reported at the 12th Congress of the European Society of Sexual Medicine (ESSM). “Since Peyronie’s was initially described more than 250 years ago, no important developments have been made regarding its physiology and pathophysiology, and no significant progress has been made with regard to treatment,” commented Juza Chen, MD, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, speaking here on November 16. Dr. Chen and colleagues reviewed the medical records of 45 men (mean age 54 years, range 26 to 65 years), who were treated with verapamil for Peyronie’s plaque. In the acute inflammatory stage, patients may describe penile pain during erection or sexual activity, while later stages are characterised by progressive fibrosis following the development of a palpable plaque, Dr. Chen noted. There are multiple conservative treatments for Peyronie’s disease, he continued. With intralesional injections, it is believed that direct delivery of medications into the affected plaque ensures a high local concentration of the drug and decreases systemic side effects. Verapamil is one of many substances that have been tested in this setting, Dr. Chen observed. Because it is a calcium channel blocker, investigators have theorised that it will be able to alter fibroblast production and consequently decrease collagenase production. All patients enrolled in the present study had failed at least 3 months of treatment with vitamin E and/or colchicine. Each patient was treated for 8 weeks by a once-weekly intralesional injection of verapamil 10 mg after local anaesthesia had been applied to the injection site. At 3 months after the last injection, only 1 man reported significant correction of his curvature. More than half (15 of 27) of the men who had complained of pain during erections, however, reported a reduction in their pain. Erectile function did not significantly improve after treatment, and only 1 of 13 men who was unable to achieve penetration pretreatment reported successful penetration post treatment. Overall, the results demonstrate that verapamil reduces pain during erection, but it does not improve vaginal penetration or erectile function, Dr. Chen said. [Presentation title: Effectiveness and Safety of Intra-lesional Injection of Verapamil in Patients With Peyronie’s Plaque. Abstract PO-07-011]
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