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HDL Cholesterol Inversely Associated With Cancer Risk: Presented at AHA By Bruce Sylvester ORLANDO, Fla -- November 16, 2009 -- Researchers report a significant inverse relationship between high-density lipoprotein cholesterol (HDL-C) and incident cancer, and confirm that the relationship is independent of low-density lipoprotein cholesterol (LDL-C), age, body mass index (BMI), and smoking status. The findings were presented here on November 15 at the American Heart Association (AHA) Scientific Sessions 2009. Presenter and investigator Richard Karas, MD, PhD, Tufts Medical Center, Boston, Massachusetts, said, “For many years, we’ve had evidence that low levels of total cholesterol are associated with increased risk of cancer. We looked specifically at LDL[-C] and found that, as with total cholesterol, low levels of LDL[-C] are also associated with increased cancer risk. That [made] us more interested in this relationship between cholesterol levels and cancer, and we realised that no one had really ever looked systematically at whether HDL-C levels are associated with increased risk of cancer.” Using a MEDLINE search, the researchers identified eligible lipid intervention, randomised, controlled trials with 1,000 or more person-years of follow-up which also provided baseline HDL-C data and rates of incident cancer. The investigators identified 21 eligible studies, with 25 drug intervention arms and 20 control arms. There were 73,319 subjects in the intervention cohorts and 66,525 subjects in the control arms. The median duration of follow-up was 5 years with a cumulative exposure of 586,528 person-years. The analysis included 7,928 incident cancers appearing during the 5 years of follow-up. The investigators found a significant inverse relationship between baseline HDL-C levels and the rate of incident cancer, reporting that every 10 mg/dL increase in HDL-C was associated with a 24% (95% CI: 1%-41%) relative reduction in the cancer rate (P = .05). The significant inverse relationship between baseline HDL-C and incident cancer rate persisted after adjustments for baseline LDL-C, age, BMI, and smoking status -- with every 10-mg/dL increase in HDL-C associated with a 21% (95% CI: 8%-33%) relative reduction in incident cancer (P = .004). They also found a significant inverse relationship between baseline LDL-C and the rate of incident cancer, with every 10-mg/dL reduction in LDL-C associated with a 14% (95% CI: 9%-18%) relative increase in the cancer rate (P < .001). There was a significant direct relationship between both age and BMI and rate of incident cancer, with every 5-year increase in age associated with a 28% (95% CI: 16%-42%) relative increase in cancer (P < .001) and every 1-kg/m2 increase in BMI associated with an 18% (95% CI: 6%-31%) relative increase in the cancer rate (P = .003). The investigators concluded, “The current systematic analysis is the first to report a strong and significant inverse relationship between baseline HDL-C and the rate of incident cancer, which is independent of LDL-C, age, BMI and smoking status.” The study was researcher initiated. [Presentation title: High-Density Lipoprotein Cholesterol Levels Are Inversely Associated With Cancer Risk. Abstract 857] E-mail this page to a friend or colleague! To print, use this version