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| |  Collagen Fleece Provides Good Defect Coverage After Surgery for Peyronie’s Disease: Presented at ESSM By Jill Stein LYON, France -- November 16, 2009 -- Defect coverage by a collagen fleece following partial plaque excision to correct penile curvature secondary to Peyronie’s disease shows promise in a recent study, researchers announced at the 12th Congress of the European Society of Sexual Medicine (ESSM). Georgios Hatzichristodoulou, MD, Technische Universität München, Munich, Germany, and colleagues presented early results from a trial of 76 men with stable Peyronie’s disease who were unable to perform coitus. A collagen fleece coated with a topical fibrin-based tissue sealant was used for penile defect coverage after corrective partial plaque excision or incision. A variety of materials are typically used to cover the defect of the tunica albuginea, Dr. Hatzichristodoulou explained here at his presentation on November 16. All materials, autologous or nonautologous, he noted, need to be “precisely adjusted and sewn into the defect, which can increase operating time and cause defects when the autologous material is removed.” Sixty-five of the patients in the study had dorsal penile deviation, 7 had lateral left deviation, and 4 had ventral deviation. The study excluded men with erectile dysfunction. Overall, 65 patients underwent partial plaque excision, 3 had plaque incision, and 8 had a Nesbit procedure. Results showed “very good” correction in 64 patients (84.2%). Twenty-seven patients (35.5%) had erections after 4.9 days post operation. Twenty-two patients (28.9%) developed a postoperative haematoma, which dissolved in most cases, and 70 patients (92.1%) had postoperative glans sensibility. Dr. Hatzichristodoulou said these results are on a par with the results of other surgical procedures with respect to treatment success, complications, glans sensibility, and the patient’s ability to obtain an erection. Besides a shorter operating time and ease of use, the procedure employed by Dr. Hatzichristodoulou’s team provided an additional haemostatic effect. He emphasised, however, that longer follow-up is needed, and additional clinical outcomes need to be measured to gauge the true usefulness of the procedure. [Presentation title: Correction of Peyronie’s Curvature by Partial Plaque Excision and Defect Coverage With Collagen Fleece -- Early Results of a Prospective, Multicenter Study. Abstract PO-07-004]
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