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Male Factor Infertility Associated With Comorbidities ARNHEM, the Netherlands -- November 11, 2009 -- A study published in the December issue of the journal European Urology shows that male factor infertility is associated with a number of medical comorbidities, as objectively scored with the hospital-based Charlson Comorbidity Index (CCI). Andrea Salonia, MD, Department of Urology, University Vita Salute San Raffaele Hospital, Milan, Italy, and colleagues conducted a prospective case-controlled study in 344 44 European Caucasian men aged 18 to 60 years with MFI. “Because a greater prevalence of cancers among men with abnormalities in fertility has been reported, our hypothesis was that men with male factor infertility (MFI) may also suffer from a higher rate of certain disorders other than cancers when compared with the general, age-comparable fertile population,” said Dr. Salonia. “The clinical observation of a significant rate of diseases among men with MFI prompted us to examine whether those patients are less healthy than age-comparable fertile men, as objectively scored with a comorbidity index, regardless of the reasons for infertility.” From September 2006 to September 2007, the men with MFI were compared with a control group of 293 age-comparable fertile European Caucasian men. Comorbidities of patients and fertile men were objectively scored with the CCI according to the International Classification of Diseases modified ninth version (ICD-9-CM) codes. The study provides novel evidence that MFI accounts for a higher CCI, which may be considered a reliable proxy of a lower general health status, regardless of the etiology of pure MFI. “Since the current sample size is limited, we cannot derive general conclusions; therefore, additional studies in larger population-based samples are needed to confirm these results,” said Dr. Salonia. SOURCE: European Association of Urology E-mail this page to a friend or colleague! To print, use this version