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Age-Specific Evaluation of HPV DNA Testing versus Cytology Screening BETHESDA, Md -- November 11, 2009 -- Human papillomavirus (HPV) DNA testing with cytology triage is more sensitive than conventional cytology screening for detecting cervical lesions, according to a study published online November 9 in the Journal of the National Cancer Institute. Cytology triage in HPV-positive women can improve specificity. HPV DNA testing has shown higher sensitivity than conventional cytology screening for detecting cervical lesions, but it is uncertain whether the higher sensitivity is dependent on the age of the woman being screened. Maarit Leinonen, MD, Mass Screening Registry, Finnish Cancer Registry, Helsinki, Finland, and colleagues compared the age-specific performance of primary HPV DNA screening with that of conventional cytology screening. Women aged 25 to 65 years were sent randomised invitations for HPV DNA testing with cytology triage or conventional screening. Overall, primary HPV DNA screening with cytology triage was more sensitive than conventional screening for detecting cervical lesions. Among women aged younger than 35 years, those who got HPV DNA screening were referred for colposcopy more often than those who got conventional screening. Among women aged 35 years or older, HPV DNA testing with cytology triage was more sensitive and more specific than conventional screening, had a higher precision rate, and was associated with fewer colposcopy referrals and follow-up tests. “In countries like Finland that have a well-organised cervical screening program and low incidence of cervical cancer, new interventions are expected to provide only small increases in a screening program’s efficacy,” the authors wrote. “Nevertheless, our results support the use of HPV DNA testing with cytology triage in primary cervical screening.” SOURCE: Journal of the National Cancer Institute E-mail this page to a friend or colleague! To print, use this version