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Adding Ropinirole to Existing Treatment Effective for Patients With Refractory Fibromyalgia: Presented at ECNP By Jenny Powers ISTANBUL, Turkey -- September 19, 2009 -- Ropinirole as an add-on treatment may be an effective treatment option for patients with fibromyalgia who have not achieved a satisfactory response to previous treatment, according to study presented here September 15 at the 22nd European College of Neuropsychopharmacology (ECNP) Congress. Juan S. Vilchez, MD, Instituto de Neurociencias, Universidad de Granada, Granada, Spain, and colleagues conducted an open-label trial involving 28 patients aged 27 to 67 years with fibromyalgia, according to the American College of Rheumatology criteria, who were refractory to previous fibromyalgia treatments. Patients received ropinirole 0.25 mg at night in addition to their current treatment. Dose adjustments were done at 2-week intervals according to patient response. Final daily doses ranged from 1 to 4 mg and patient status was evaluated at baseline and at weeks 6 and 12. The primary endpoint was the mean change from baseline in the Fibromyalgia Impact Questionnaire (FIQ) score. Secondary endpoints included mean changes from baseline in the Pittsburgh Sleep Quality Index (PSQI), the Brief Pain Inventory (BPI), the Hospital Anxiety and Depression Scale (HADS) scores, and change in the Short Form-36 Health Survey (SF-36) score. Scores in the FIQ, BPI, PSQI, and HADS, significantly decreased for patients. Four of the 8 scales of the SF-36 showed a significant increase in score including Bodily Pain, Global Health, Mental Health, and Vitality. However side effects were high and included nausea/vomiting (28.6%), dizziness (21.4%), drowsiness (21.4%), headache (17.9%), tachycardia (10.7%), tremor (10.7%), and peripheral oedema (10.7%). Ten patients withdrew from the study, of which 6 were attributable to drug-related side effects. The authors noted that patients in the study were already receiving 1 or more drugs for fibromyalgia and associated comorbidities could have contributed to the intolerance of ropinirole, warranting further research. [Presentation title: Ropinirole as a Coadjuvant Treatment in the Management of Refractory Patients With Fibromyalgia: A Case Series Abstract: P.1.c.032] E-mail this page to a friend or colleague! To print, use this version