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Minimally Invasive Treatment Found Effective for Early-Stage Oesophageal Cancer ROCHESTER, Minn -- September 2, 2009 -- Researchers have found that early stage cancers of the oesophagus can be treated as effectively by less-invasive, organ-sparing endoscopic therapy as compared with more complex surgical removal of the oesophagus, according to a study published in the September issue of the journal Gastroenterology. “Traditionally, oesophageal cancer patients undergo a complicated surgery to remove the esophagus,” said lead author Ganapathy Prasad, MD, Mayo Clinic, Rochester, Minnesota. “Our team compared surgery to the use of endoscopic therapy, where a scope is inserted in the oesophagus and the cancer cells are shaved off. Our results showed the less-invasive therapy was just as effective as surgery for early-stage cancers.” In this study of 178 patients with early-stage oesophageal adenocarcinoma, 132 (74%) were treated with endoscopic mucosal resection and 46 patients (26%) were treated surgically. The endoscopic mucosal resection patients underwent a procedure where a liquid is injected under the lesion and then an endoscope is used to shave off the lesions. The other patients underwent more traditional oesophagectomy. In following these patients for 9 years, both groups had a comparable overall mortality rate of approximately 20%. Cancer recurred in 12% of patients treated endoscopically, but recurrence could be re-treated endoscopically. Dr. Prasad explained that oesophagectomy surgery patients are typically in the hospital for a week, and 30% to 50% of patients have complications post surgery. Endoscopic treatments, however, are performed in an outpatient care setting, and patients can eat full meals in a couple of days. Lead author Kenneth Wang, MD, of Mayo Clinic said that future research in this area will examine genetic markers to help determine the best course of treatment for patients with oesophageal cancer. In addition, the research team hopes to study the use of endoscopic therapy for more advanced oesophageal cancers. SOURCE: Mayo Clinic E-mail this page to a friend or colleague! To print, use this version