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Mild Glucose Intolerance in Pregnancy May Be Associated With Cardiovascular Risk OTTAWA, Ontario -- August 24, 2009 -- Mild glucose intolerance in pregnancy may be an early identifier of women who are at increased risk of heart disease in the future, according to a study published in the Canadian Medical Association Journal. In a large population-based cohort study, Ravi Retnakaran MD, University of Toronto, and Baiju R. Shah MD PhD, Institute for Clinical Evaluative Sciences (ICES), both in Toronto, Ontario, studied data on 435,696 women in Ontario who gave birth between April, 1994 and March, 1998. All women were followed until March 31, 2008. The study excluded women with pre-existing diabetes. While women with gestational diabetes have a higher risk of cardiovascular disease than those without, it previously has not been known whether mild glucose intolerance in pregnancy is associated with heart disease. The study sought to answer this question. “Women who had an abnormal glucose challenge test but then did not have gestational diabetes had an increased risk of future cardiovascular disease compared with the general population, but a lower risk than women who actually did have gestational diabetes,” said Dr. Shah. They suggest that “in women with glucose intolerance during pregnancy, type 2 diabetes and vascular disease may develop in parallel, which is consistent with the ‘common soil’ hypothesis for these conditions.” Current screening procedures for gestational diabetes might also provide a means for the early identification of women who are at risk for developing heart disease later in life. In a related commentary J. Kennedy Cruickshank, MD, and Moulinath Banerjee, MD, Manchester Royal Infirmary, University of Manchester, Manchester, United Kingdome, wrote: “What the study by Retnakaran and Shah shows is that we all have a great deal to learn from sub-clinical blood vessel changes in younger women who are likely overweight during pregnancy.” They suggest that diabetes research should focus on the blood vessel rather than glycaemia. SOURCE: Canadian Medical Association Journal E-mail this page to a friend or colleague! To print, use this version