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Cognitive Testing, Gender, and Brain Lesions May Predict MS Disease Progression Risk ST. PAUL, Minn -- July 31, 2009 -- Cognitive testing may help people with inactive or benign multiple sclerosis (MS) better predict their future with the disease, according to a study published in the July 29 online issue of the journal Neurology. Gender and brain lesions may also determine the risk of progression of MS years after diagnosis. For the study, researchers looked at the cognitive test results and brain scans of 63 people with benign MS during a period of 5 years. Of those, 43 were women and 20 were men. The cognitive tests included verbal and visual memory, attention, concentration and the speed at which the participant processed information. Brain scans revealed the number of lesions associated with MS on the person's brain. Follow-up neurologic exams were done every 6 months. The study found that nearly 30% of people with benign MS significantly worsened over the course of 5 years. People who failed more than 2 cognitive tests (out of 10 total) were 20% more likely to progress over time. Men with benign MS were nearly 3 times more likely to later experience signs of MS compared with women. People with more brain lesions detected on scans were also more likely to develop signs of the disease. "Our findings strongly suggest that a person's gender, cognitive state, and amount of lesions on the brain are important factors for predicting MS progression," said study author Maria Pia Amato, MD, University of Florence in Italy. "Our study highlights the importance of cognitively testing people with benign MS who appear to be healthy. This information might be important in tailoring the patient's treatment." SOURCE: American Academy of Neurology E-mail this page to a friend or colleague! To print, use this version