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Most Patients With HIV Respond Well to Syphilis Therapy: Presented at IAS By Ed Susman CAPE TOWN, South Africa -- July 24, 2009 -- Patients with HIV coinfected with syphilis respond well to treatment for syphilis, according to a retrospective analysis presented here at the 5th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention. The study, performed among 4,282 HIV-positive US Army personnel (from 1986-2005), showed that as many as 96% of patients who were treated for syphilis responded well to treatment. The US Army has followed HIV-positive personnel since 1986. "Contrary to prior reports seroreversion was common and syphilis treatment failure rare among HIV-infected patients in our cohort, suggesting open-access to care maybe associated with better treatment response," said Anuradha Ganesan, MD, National Naval Medicine Center and Uniformed Services University of the Health Sciences, Bethesda, Maryland, on July 20. Dr. Ganesan and colleagues identified 147 incident cases of syphilis among HIV-positive individuals. Only 6 of the patients were considered treatment failures; 108 (73%) were classified as seroreverters; and 33 were considered responders, achieving substantial decline in syphilis-related titres. All patients were men (mean age, 33 years); most of the men identified themselves as African Americans; about 25% had experienced previous syphilis diagnoses; and 124 had been diagnosed with syphilis for less than 1 year. Less than half the patients were being treated with highly active antiretroviral therapy. More than 70% of the patients seroreverted within 6 months of treatment if they had been diagnosed with syphilis for 8 months or less. If they had syphilis for 8 to 16 months, about 26% seroreverted within 6 months, and 72% seroreverted after 36 months. Twenty-four percent of the others achieved a response to treatment. "Assessing treatment response at 24 months instead of 12 months increases the proportion of patients classified as treatment responders," said Dr. Ganesan. [Presentation title: Syphilis Treatment Responses in a Cohort of HIV-Infected Patients With Open Access to Care Are Similar to Those Reported in HIV-Uninfected Patients. Abstract MOPEB017] E-mail this page to a friend or colleague! To print, use this version