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Most Patients With NNRTI Resistance Maintain Susceptibility to Etravirine: Presented at IAS By Charlene Laino CAPE TOWN, South Africa -- July 21, 2009 -- Most patients are able to maintain susceptibility to etravirine after the acquisition of non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance, researchers reported here at the 5th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention. Ezequiel Cordova, MD, Outpatient Care Department, Hospital Francisco J. Muñiz, Buenos Aires, Argentina, presented the findings on July 20 at a poster session. Virological response to etravirine is dependent on the type and number of NNRTI resistance-associated mutations, Dr. Cordova said. The aim of the study was to examine the predicted susceptibility of etravirine in patients experiencing virological failure secondary to NNRTI resistance at Francisco Muñiz Hospital between 2001 and 2008. The study involved 150 patients of which 76.7% were on an efavirenz-containing regimen and 23.3% were on nevirapine. A total of 38.7% of patients developed 1 etravirine resistance-associated mutation after NNRTI failure, 17.3% developed 2, 3.3% developed 3, and 1.3% of patients developed 4 etravirine resistance-associated mutations. The researchers then analysed etravirine resistance-associated mutations according to the weighted mutation score to predict susceptibility. This was scored as 0 to 2 being the highest response, 2.5 to 3.5 being an intermediate response, and 4 or more being reduced response. Results showed that only 6% of patients fell into the reduced response category and were no longer susceptible to etravirine, Dr. Cordova said. [Presentation title: Predicted Susceptibility of Etravirine in HIV Patients Experiencing Virological Failure Secondary to Nonnucleoside Reverse Transcriptase Inhibitor Resistance. Abstract MOPEB071] E-mail this page to a friend or colleague! To print, use this version