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Clotting in Veins Close to Skin May Be Associated With More Dangerous Deep-Vein Blood Clots CHICAGO -- July 20, 2009 -- About one-fourth of patients with superficial vein thrombosis (SVT) -- clotting in blood vessels close to the skin -- also may have the life-threatening condition deep vein thrombosis (DVT), according to a report in the July issue of Archives of Dermatology, one of the JAMA/Archives journals. Different risk factors have been reported for SVT, many of which are the same as risk factors for DVT -- varicose veins, thrombophilia, use of oral contraceptives, trauma, malignancy, or a period of immobility. “In the past, not much interest has been focused on superficial vein thrombosis because of its generally benign course. However, recent investigations showed an unsuspected association of superficial vein thrombosis with deep vein thrombosis and thromboembolism.” Barbara Binder, MD, Medical University of Graz, Austria, and colleagues studied 46 consecutive patients (32 women and 14 men) with SVT between November 2006 and June 2007. All patients underwent colour-coded duplex sonography to confirm SVT and exclude or detect DVT. Participants also reported their history of clotting events, use of oral contraceptives and compression stockings, any recent immobilisation, and active malignant disease. Laboratory tests included D-dimer levels. DVT was detected in 24% of patients with SVT and was usually asymptomatic. DVT occurred in the same leg as SVT in 73% of the patients, in the other leg in 9%, and in both legs in 18%. “The calf muscle veins were most commonly involved,” the authors wrote. “In all patients with deep vein thrombosis, the superficial vein thrombosis was located on the lower leg and the D-dimer findings were positive.” “Generally, superficial vein thrombosis is regarded as a condition with an uncomplicated course and usually is not considered to be a severe or life-threatening disease. However, the occurrence of concomitant deep vein thrombosis and/or pulmonary embolism may lead to severe complications,” they continued. “The results of this study indicate that concurrent deep vein thrombosis is more likely when superficial vein thrombosis affects the lower leg. In these cases, the deep veins should be assessed by colour-coded duplex sonography [from the inguinal region to the ankle] to exclude or confirm acute deep vein thrombosis.” SOURCE: Archives of Dermatology E-mail this page to a friend or colleague! To print, use this version