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HIV-Positive Injecting Drug Users Respond as Well as Non-Drug Injectors to First-Line Therapy: Presented at IAS By Ed Susman CAPE TOWN, South Africa -- July 27, 2009 -- HIV-positive injecting drug users (IDUs) can be treated as successfully as HIV-positive non-IDUs, researchers stated here at the 5th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention. "There is a common belief that injecting drug use is associated with lower uptake, retention, and success of antiretroviral treatment in HIV-infected patients, although studies in western countries have shown this is not always the case," said Rudi Wisaksana, MD, Department of Internal Medicine, Hasan Sadikin Hospital of Padjadjaram University, Bandung, Indonesia. In an examination of response to first-line treatment for HIV infection, Dr. Wisaksana said that 53% of 530 HIV-positive IDUs were alive on their original treatment regimen after 6 months of treatment compared with 55.2% of 96 HIV-positive non-IDUs. Another 14% of the IDUs were alive on an alternate regimen as were 7.3% of the non-IDUs, Dr. Wisaksana said at a poster presentation on July 20. Of the IDUs, 15.7% had died compared with 18.8% of the non-IDUs (P = .46), a nonsignificant difference. About 13% of patients in each group were lost to follow-up. "HIV-patients with a history of injecting drug use in this setting were mostly young males, presenting with hepatitis C virus coinfection, and more severe immunosuppression than HIV-patients without a history of injecting drug use," said Dr. Wisaksana. About 91% of the IDUs were men compared with only 27.1% of the non-IDUs. The mean age for the patients in the study was 28 years. About half the IDUs were single while 55.8% of the non-IDUs were married. About 87.7% of the IDUs were positive for hepatitis C virus compared with none of the non-IDUs, and about 8% of IDUs showed exposure to hepatitis B virus compared with 3.3% of non-IDUs. "We found that injecting drug use did not have a negative effect on mortality, retention in treatment, and virological or immunological response to antiretroviral therapy," Dr. Wisaksana said. [Presentation title: Response to First Line Antiretroviral Therapy Among HIV-Infected Patients With and Without a History of Injecting Drug Use in Indonesia. Abstract MOPEB060] E-mail this page to a friend or colleague! To print, use this version