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Intravitreal Bevacizumab Can Stabilise Vision in Patients With Degenerative Eye Diseases: Presented at COS By Louise Gagnon TORONTO -- June 29, 2009 -- Bevacizumab is effective in treating several ophthalmological conditions that can threaten visual acuity, according to a study presented here at the 72nd Annual Meeting and Exhibition of the Canadian Ophthalmological Society (COS). Matthew Tennant, MD, University of Alberta, Edmonton, Alberta, presented the results on June 22. The study prospectively examined the effect of administering bevacizumab in an intravitreal manner in 17 eyes of 17 patients in a nonrandomised fashion. Patients were aged 50 to 85 years. Ten of the patients had choroidal neovascularization, secondary to age-related macular degeneration (AMD); 6 had central vascular occlusive disease; and 1 had branch retinal vein occlusion. At baseline, investigators measured retinal responses with multifocal electroretinogram (mfERG), macular thickness with optical coherence tomography (OCT) and visual acuity according to the Early Treatment Diabetic Retinopathy Study. They took the same measurements 3 months after injecting patients with bevacizumab 1.25 mg. They observed enhancements in the retinal responses and macular thickness at 3-months follow-up. At 3 months, mfERG amplitudes for the central rings rose from 13.08 to 17.50 nV/deg2 (P = .001). According to OCT findings, macular thickness decreased after treatment, with improvement for the central fovea from 0.32 to 0.20 mm3 and improvement for the total macula from 8.86 to 7.04 mm3 (P < .001). Progress was seen in visual acuity, with patients able to read 57 letters versus 55 at baseline, but the advance was not statistically significant (P = .33). Patients experienced no adverse events with the administration of bevacizumab. "The therapy did stabilise the vision of patients for 3 months," said Dr. Tennant, who noted that the researchers are continuing to study the effect of bevacizumab, particularly in the treatment of AMD. [Presentation title: The Effect of Bevacizumab on the Macular Function of Patients With Choroidal Neovascularization and Vascular Occlusive Disease. Abstract P35] E-mail this page to a friend or colleague! To print, use this version