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Inducible Clindamycin Resistance Prevalent in Paediatric Patients With Suspected Staphylococcal Infection: Presented at ESPID By Lynda Jackson BRUSSELS, Belgium -- June 16, 2009 -- According to a study presented here at the 27th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID), physicians should be aware of inducible clindamycin resistance (ICR) when treating paediatric patients with suspected staphylococcal infections. Dror S. Shouval, MD, Department of Pediatrics C, Schneider Children's Medical Center, Petah Tiqva, Israel, presented the study on June 11. To assess the prevalence of ICR among paediatric methicillin-sensitive Staphylococcus aureus (MSSA) infections in Israel and to evaluate the clonality of these isolates, Dr. Shouval and colleagues conducted a retrospective analysis of MSSA infections from January 2006 to June 2007. The researchers performed a full antibiogram for all isolates and determined phage typing. Selected isolates were analysed by pulsed-field gel electrophoresis (PFGE) to assess their clonality. A total of 240 MSSA isolates were recovered during the study period, and ICR was detected in 62 patients (25.8%). Phage type analysis demonstrated that 38 (62.3%) of the 61 ICR isolates found were sensitive to phage 2, compared with 42 (24.4%) of the 172 isolates not expressing ICR (P = .01). PFGE analysis demonstrated that phage type 2 isolates expressing ICR belonged to the same clone, which was different from ICR isolates sensitive to other phages and different from phage 2 isolates not displaying ICR. Based on the results of the study, the researchers recommend that physicians not rely on clindamycin alone as treatment, especially with serious infections. [Presentation title: Prevalence and Molecular Analysis of Inducible Clindamycin Resistance Among Methicillin Sensitive Staphylococcus Aureus Isolates From Pediatric Patients in Israel. Abstract P017] E-mail this page to a friend or colleague! To print, use this version