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Cardiovascular Risk Factors in Patients With Depression May Impede Response to Antidepressants: Presented at APA By Roberta Friedman, PhD SAN FRANCISCO -- May 21, 2009 -- Patients with depression who also have cardiovascular disease risk factors are less likely to respond to antidepressants, according to a study presented here on May 20 at the 162nd Annual Meeting of the American Psychiatric Association (APA). Dale D'Mello, MD, Michigan State University, and St. Lawrence/Sparrow Hospital, Lansing, Michigan, and colleagues compared patients who received electroconvulsive shock therapy (ECT) after failing to respond to medication for depression to those patients who did respond to medical therapies. Patients (n = 187; 119 female) were from an adult psychiatry unit at the St. Lawrence/Sparrow Hospital. They were given a brief questionnaire on risk factors for cardiovascular disease during the period from 2006 to 2008. Mean body mass index (BMI) was 30. There were 43 patients who did not respond to medical treatment and who had ECT. These patients had relative risk of the following factors for cardiovascular disease: 1.6 for hypertension, 2.4 for diabetes, 1.8 for dyslipidaemia, and 1.6 for obesity. Diabetes was a factor affecting the age of onset of depression, which was 36 years in patients with diabetes, and 30 years for those not diabetic (P < .05). For dyslipidaemia, age of onset of depression was 34 years, but 29 years in those without dyslipidaemia (P < .05). Hypertension also turned out to be a significant factor affecting the age at onset of depression, 33 years in hypertensives and 29 years in those without high blood pressure (P < .05). "Preventing diabetes and dyslipidaemia may prevent depression or improve its outcome," Dr. D'Mello said. Dr. D'Mello acknowledged the limitation of the study in that interviews were not used and the questionnaire was extremely brief. [Presentation title: Do Cardiovascular Risk Factors Impede Antidepressant Treatment Response? Abstract 70] E-mail this page to a friend or colleague! To print, use this version