Overnight Dialysis Proves to be Effective, Safe, and Convenient for Patients
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Overnight Dialysis Proves to be Effective, Safe, and Convenient for Patients

WASHINGTON, DC -- May 21, 2009 -- Overnight dialysis is more convenient for some patients and offers significant benefits over shorter daytime treatments, according to a study appearing early online and in an upcoming issue of the Clinical Journal of the American Society Nephrology.

The findings indicate that overnight dialysis is a viable alternative for patients with irreversible kidney disease, particularly in dialysis clinics where there are constraints on time and resources.

Dialysis is usually done in 3 to 5 hours of treatments 3 days a week. Unfortunately, even this difficult schedule may not be frequent enough to maintain many patients' health. Some clinics offer an alternative of 3 weekly overnight dialysis sessions lasting 6 hours or more.

To test the effectiveness of this alternative schedule, Joanna Ruth Powell, MD, Western Infirmary, Glasgow, Scotland, and colleagues compared the health of patients who received long overnight dialysis sessions with those who received conventional dialysis during the day.

During 10 years of study, 146 patients in their clinic chose long overnight dialysis (approximately 11% of their dialysis patients). Patients ranged vastly in age with 30 aged older than 70 years.

The overnight therapy was well tolerated with only a third of patients converting back to conventional dialysis after an average of approximately 2 years, mostly for preferential rather than medical reasons.

The investigators studied various health parameters of 106 of their patients, with equal numbers receiving overnight dialysis and conventional dialysis for at least 1 year. The patients who underwent overnight dialysis had lower rates of anaemia and reduced levels of urea in their blood.

Previous studies have found that overnight dialysis also reduces patients' blood pressure, blood phosphate levels, and risk of premature death compared with conventional dialysis. However, this study did not observe these benefits, however.

The researchers concluded that long overnight dialysis is a practical way for clinics to offer longer dialysis sessions that are well tolerated by most patients with kidney disease.

SOURCE: American Society of Nephrology

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