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Age-Related Macular Degeneration Associated With Cognitive Impairment CHICAGO -- May 11, 2009 -- Older adults with low scores on tests of cognitive function, including thinking, learning and memory appear more likely to have the early stages of age-related macular degeneration (AMD), according to a study published in the May issue of Archives of Ophthalmology. "…Clinical studies suggest that AMD and Alzheimer's disease share similar vascular risk factors, such as hypertension and cigarette smoking," the authors wrote. "Both AMD and Alzheimer's disease have been linked to an increased risk of stroke." Michelle L. Baker, MD, University of Melbourne, Victoria, Australia, and colleagues assessed 2,088 individuals aged 69 to 97 years. Participants underwent cognitive testing, retinal photography for the detection of AMD and an extensive assessment of artery disease and its risk factors including blood pressure, smoking status, and body mass index (BMI). After controlling for age, sex, race, and the centre at which they participated in the study, the one-fourth of individuals with the lowest scores on one cognitive test were twice as likely to have early-stage AMD as were individuals with higher scores. However, there was no association between AMD and scores on a second cognitive test, dementia or Alzheimer's disease. "In conclusion, we found an association between low cognitive function and early AMD in this older population," the authors wrote. "These data, along with others, provide further support that AMD and cognitive impairment may share similar complex pathogenesis and risk factors." SOURCE: Archives of Ophthalmology E-mail this page to a friend or colleague! To print, use this version