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Hypoglycaemia Poses Serious Health Threat for Patients With CKD WASHINGTON, DC -- May 7, 2009 -- Hypoglycaemia poses a serious health threat for patients with chronic kidney disease (CKD), according to a study released early online and appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology. The findings indicate that hypoglycaemia may account for some portion of the excess heart-related deaths seen in patients with CKD. Jeffrey C. Fink, MD, University of Maryland Medical System, and Maureen F. Moen, University of Maryland School of Medicine, Baltimore, Maryland, and colleagues designed a study to examine the incidence of hypoglycaemia among patients with CKD and to determine whether the condition might contribute to patients' deaths. The researchers assessed the incidence of hypoglycaemia in patients with CKD relative to patients without CKD, both with and without diabetes, and they examined the association of hypoglycaemia with subsequent near term deaths (1 day after blood glucose measurement). Analysis included information from 243,222 individuals cared for at the Veterans Health Administration. The incidence of hypoglycaemia was higher in patients with CKD versus without, both among patients with diabetes and among those without. The risk of hypoglycaemia was highest in individuals with both CKD and diabetes. Hypoglycaemia increased patients' risk of dying in the near term. According to the authors, there was a reduced risk of near term death in individuals with CKD relative to those without and this attenuation in the risk of death might relate to an increased quality of care in these patients with CKD relative to diabetic patients without CKD. "The association of hypoglycaemia with 1-day mortality underscores the significance of this metabolic disturbance in patients with diabetes and chronic kidney disease," said Dr. Fink. While details on therapy were not included in this study, the findings are consistent with others that have shown that putting patients on intensive glucose-lowering medications can lead to an increased incidence of hypoglycaemia and does not prolong their survival. SOURCE: American Society of Nephrology E-mail this page to a friend or colleague! To print, use this version