Sleep Apnoea May Not Be Closely Linked to Heart Failure Severity
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Sleep Apnoea May Not Be Closely Linked to Heart Failure Severity

PHILADELPHIA -- May 6, 2009 -- Obstructive sleep apnoea (OSA) and central sleep apnoea (CSA) are not markedly decreased in heart failure (HF) patients managed with beta-blockers and spironolactone, according to a study published in the March issue of Journal of Cardiac Failure.

The high prevalence of OSA and CSA in patients with heart failure has been well recognised in recent years, but there is limited information about secular trends in its occurrence, despite important advances in the management of these patients since this phenomenon was recognised.

The study involved 218 heart failure patients with reduced ejection fraction (mean 24.7%) who underwent sleep studies between 1997 and 2004.

Overall 47% had moderate to severe OSA or CSA. Both conditions were more prevalent in older age and in men. OSA was associated with greater body mass index (BMI), whereas CSA was associated with atrial fibrillation, hypocapnia, and diuretic use.

These findings may have important implications for care HF patients with a prevalence of OSA and CSA because effective treatment of these sleep-related breathing disorders may be beneficial in addition to treatment with beta-blockers and sprionlactone.

"This study reemphasises the high prevalence of sleep apnoea, but unfortunately shows that despite the improvements in medical therapy and associated improvements in outcomes, the prevalence of sleep apnoea has not diminished," commented Barry M. Massie, MD, University of California at San Francisco, and San Francisco V.A. Medical Center, San Francisco, California, in an accompanying editorial.

"This may indicate that the severity of heart failure and the occurrence of sleep apnoea are not closely linked, but that there are common risk factors for both, such as older age, male sex, and obesity."

SOURCE: Elsevier

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