If this is not your name, click here.
| | If this is not your name, click here. | | |
| | Contact Us | Order Now | Journals | Bookstore | Register a colleague | | |
| |  Toddlers With Autism More Likely to Have an Enlarged Amygdala CHICAGO -- May 4, 2009 -- Toddlers with autism appear more likely to have an enlarged amygdala, a brain area associated with numerous functions, including the processing of faces and emotion, according to a study published in the May issue of Archives of General Psychiatry. In addition, this brain abnormality appears to be associated with the ability to share attention with others, a fundamental ability thought to predict later social and language function in children with autism. "Converging evidence from magnetic resonance imaging (MRI), head circumference, and postmortem studies suggests that brain volume enlargement is a characteristic feature of autism, with its onset most likely occurring in the latter part of the first year of life," the authors wrote. Based both on its function and studies of changes in its structure, the amygdala has been identified as a brain area potentially associated with autism. Matthew W. Mosconi, PhD, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, and colleagues conducted an magnetic resonance imaging (MRI) study involving 50 children with autism and 33 control children. Participating children underwent brain scans along with testing of certain behavioural features of autism at age 2 and 4 years. This included a measure of joint attention, which involves following another person's gaze to initiate a shared experience. Compared with control children, children with autism were more likely to have amygdala enlargement both at age 2 and age 4. "These findings suggest that, consistent with a previous report of head circumference growth rates in autism and studies of amygdala volume in childhood, amygdala growth trajectories are accelerated before age 2 years in autism and remain enlarged during early childhood," the authors wrote. "Moreover, amygdala enlargement in 2-year-old children with autism is disproportionate to overall brain enlargement and remains disproportionate at age 4 years." Among children with autism, amygdala volume was associated with an increase in joint attention ability at age 4. This suggests that alterations to this brain structure may be associated with a core deficit of autism, the authors noted. "The amygdala plays a critical role in early-stage processing of facial expression and in alerting cortical areas to the emotional significance of an event," the authors concluded. "Amygdala disturbances early in development, therefore, disrupt the appropriate assignment of emotional significance to faces and social interaction," the authors concluded. Continued follow-up of research participants, now under way, will help determine whether amygdala growth rates continue at the same rate or undergo another period of accelerated growth or a period of decelerated growth in autistic children after age 4. SOURCE: Archives of General Psychiatry
|
