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Moderate Kidney Disease Can Increase Risk of Cancer in Older Men WASHINGTON, DC -- April 30, 2009 -- Moderate kidney disease increases an older man's risk of developing certain cancers, according to a study appearing in the online April 30 issue of the Journal of the American Society Nephrology. Given that chronic kidney disease (CKD) affects about a third of older men, maintaining kidney function could help prevent cancer in the general population. People with end-stage renal disease (ESRD) and kidney transplant recipients are at increased risk of developing cancer, but little is known about the cancer risks of individuals with milder kidney dysfunction. To investigate, Germaine Wong, MD, Children's Hospital at Westmead, Westmead, Australia, and colleagues studied data from 3,654 Australians aged 49 to 97 years who were followed for an average of 10 years. They observed individuals who had decreased kidney function for an increased risk of developing cancer. The researchers discovered that men with moderate kidney dysfunction had a 39% increased risk of developing cancer over the risk seen in men with normal kidney function. Risk increased as kidney function declined, and men with significant kidney dysfunction had a 3-fold increased risk above normal. The risk for lung and urinary tract cancers, but not prostate cancer, was higher among men with kidney disease. Some evidence suggests that inflammation caused by chronic kidney disease (CKD) may contribute to the development of cancer. Other studies have found an association between Vitamin D deficiency, which is highly prevalent among people with moderately reduced kidney function, and increased cancer risk. Additional research is needed to uncover the underlying mechanisms involved in the cancer-kidney disease link found in this study and to explain why a link was not found in women. "Men with CKD should be aware of cancer prevention and screening for early detection," said Dr. Wong. "CKD prevention may be a worthwhile strategy for preventing and reducing cancer risk in the general population." SOURCE: American Society of Nephrology E-mail this page to a friend or colleague! To print, use this version