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Psoriasis Associated With Hypertension, Diabetes in Women CHICAGO -- April 20, 2009 -- Women with psoriasis appear to have an increased risk for developing diabetes and hypertension, according to a study published in the April issue of Archives of Dermatology. Abrar A. Qureshi, MD, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, and colleagues studied 78,061 women involved in the Nurses' Health Study 2, a group of female nurses aged 27 to 44 years in 1991. Participants -- all of whom were free of diabetes and hypertension at the beginning of the study -- responded to a survey which included a question about lifetime history of psoriasis in 2005 and were assessed for the development of diabetes or hypertension during the 14-year follow-up. Of the women, 1,813 (2.3%) reported a diagnosis of psoriasis. A total of 1,560 (2%) developed diabetes and 15,724 (20%) developed hypertension. Women with psoriasis were 63% more likely to develop diabetes and 17% more likely to develop hypertension than women without psoriasis. These associations remained strong even after the researchers considered age, body mass index (BMI), and smoking status. Inflammation could be a biologically plausible explanation for the association between psoriasis and hypertension as well as that between psoriasis and diabetes, the authors noted. Alternatively, systemic steroid therapy or other treatments for psoriasis may promote development of diabetes or hypertension. "These data illustrate the importance of considering psoriasis a systemic disorder rather than simply a skin disease," the authors concluded. "Further research is needed to better understand the mechanisms underlying these associations and to find out whether psoriasis therapy can reduce the risk for diabetes and hypertension." SOURCE: Archives of Dermatology E-mail this page to a friend or colleague! To print, use this version