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ERRATUM: Mometasone Furoate/Formoterol Shows Similar Efficacy to Fluticasone Propionate/Salmeterol in Severe Asthma: Presented at AAAAI The following report, which originally appeared on March 20, 2009, described the wrong dosages for drugs in the study. We apologise for any inconvenience this error might have caused. By Em Brown WASHINGTON, DC -- March 25, 2009 -- Mometasone furoate/formoterol (MF/F) via a single metered-dose inhaler (MDI) is a safe, effective alternative to fluticasone propionate/salmeterol (FP/S) for the treatment of moderate to severe persistent asthma, investigators stated here on March 17 at the American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting. Jorge F. Maspero, MD, Fundacion CIDEA, Allergy and Respiratory Research Institute, Buenos Aires, Argentina, presented the results of a randomised study assessing the long-term safety of MF/F in patients with moderate to severe asthma previously treated with medium- to high-dose inhaled corticosteroids. A total of 404 patients, aged 12 years and older, were randomised to twice daily doses of MF/F 200/10 mcg (n = 141); MF/F 440/10 mcg (n = 130); FP/S 250/50 mcg (n = 68); or FP/S 500/50 mcg (n = 65), for 1 year. All regimens were well tolerated, with similar rates of adverse events. The most common treatment-related adverse events in the MF/F group were dysphonia (5% medium-dose group, 3.1% high-dose group) and headache (4.3% medium-dose group, 3.1% high-dose group). In patients receiving FP/S, headache occurred in 5.9% of the medium-dose group and in 1.5% of those on the higher dose. Arthralgia occurred in 4.4% of the medium-dose group and 1.5% of high-dose group. Oral candidiasis was uncommon, occurring in 1.1% of mometasone-treated patients and in 2.2% of fluticasone-treated patients. "Mometasone furoate/formoterol was well tolerated over 1 year at medium and high doses, with a safety profile similar to fluticasone/salmeterol and no unusual or unexpected adverse events," Dr. Maspero concluded. Funding for this study was provided by a grant from Schering-Plough. [Presentation title: Long-Term Safety and Tolerability of Two Doses of Mometasone Furoate/Formoterol (MF/F) Combination, Administered Via a Metered-Dose Inhaler, for the Treatment of Moderate-to-Severe Persistent Asthma. Abstract 606] E-mail this page to a friend or colleague! To print, use this version