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Poorly Controlled Asthma Diminishes Quality of Life: Presented at AAAAI By Maggie Schwarz WASHINGTON, DC -- March 18, 2009 -- Poorly-controlled asthma has detrimental effects on quality of life in patients with moderate to severe asthma, according to study results presented here at the American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting. Debra A. Wertz, PharmD, Healthcore, Inc., Wilmington, Delaware, and colleagues compared the impact of patient-reported asthma control on their quality of life and presented the results on March 15. Previous research showed that poor asthma control is associated with a significant degree of functional impairment, Dr. Wertz noted. Her research team administered the cross-sectional Asthma Therapy Assessment Questionnaire (ATAQ) via telephone to assess asthma care, symptom control, and quality of life. The Mini-Asthma Quality of Life Questionnaire (Mini-AQLQ) was used to assess the effect of disease signs and symptoms on quality of life. A total of 15 items are assessed in the Mini-AQLQ in 4 domains: symptoms (5 items), activity limitation (4 items), emotional function (3 items), and environmental stimuli (3 items). A total of 1,199 patients completed the questionnaires in 2 rounds. Age and comorbidities were similar between groups. On the ATAQ, 14% of round 1 and 11% of round 2 respondents had a score of 0; 12% of round 1 and 10% of round 2 had scores of 3 or 4. Decreasing levels of asthma control were associated with greater functional impairment on Mini-AQLQ in both rounds. Shortness of breath and chest tightness were reported "sometimes" to "all of the time" in the majority of patients with poor asthma control. Responses to Mini-AQLQ questions were similar between groups. Depression was reported in significantly more patients whose asthma was very poorly controlled than in those whose asthma was well controlled or not well controlled. Dr. Wertz concluded that poorly controlled asthma is associated with reduced quality of life in moderate to severe asthma patients. Funding for this study was provided by Genentech, Inc., and Novartis Pharmaceuticals Corporation. [Presentation title: Impact of Asthma Control on Quality of Life. Abstract 436] E-mail this page to a friend or colleague! To print, use this version