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Having a Parent With Dementia, ApoEe4 Gene Increases Risk of Memory Loss SEATTLE, Wash -- February 20, 2009 -- People who have parents diagnosed with Alzheimer's disease (AD) or dementia may be more likely to have memory loss themselves in middle age, according to a study released today that will be presented at the American Academy of Neurology's 61st Annual Meeting in Seattle, Washington, in April. For the study, researchers used the Framingham Heart Study to follow 3 generations of participants to study risk factors of AD and other diseases. A total of 715 people belonging to the second generation of the Framingham Heart Study with an average age of 59 years were included in the research. A group of 282 people had 1 or both parents with diagnosed dementia. The other group of 433 people had parents without dementia. Researchers tested both groups for the ApoEe4 gene. Among people who were carriers of the ApoEe4 gene, those who had parents with AD or other dementia had 2 to 3 times the risk of having low verbal and visual memory performances than people who did not have parents with AD. "This result in people with parents who have Alzheimer's disease is equivalent to about 15 years of brain aging," said study author Stephanie Debette, MD, Boston University, Boston, Massachusetts. "The effect was largely limited to those who have the ApoEe4 gene, which supports the idea that the gene is probably at least partially responsible for the transmission of Alzheimer's disease risk between generations." "However, all of these individuals were functioning normally, and only further testing can determine whether the poorer performance on memory testing in middle age would lead to an increased risk of developing Alzheimer's disease or other dementia later in life," she said. SOURCE: American Academy of Neurology E-mail this page to a friend or colleague! To print, use this version