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Gene May Lead to Early Onset of Brain Tumour ST. PAUL, Minn -- January 26, 2009 -- People with a particular gene variant may be more likely to develop brain tumours, and at an earlier age, than people without the gene, according to a study published in the January 27 issue of the journal Neurology. The study involved 254 people with brain tumours and 238 people with no cancers. All those with tumours had glioblastoma multiforme. Through blood samples, researchers looked at the tumour suppressor TP53 gene. People aged younger than 45 years with brain tumours were more likely to have the Pro/Pro variant of the gene than older people with brain tumours or the healthy participants. A total of 20.6% of the young people with brain tumours had the gene variant, compared with 6.4% of the older people with brain tumours, and 5.9% of the healthy participants. "Eventually we may be able to use this knowledge to help identify people who have a higher risk of developing brain tumours at an early age," said study author Marc Sanson, MD, French National Institute of Health and Medical Research, Paris, France. "However the risk of this population remains low, even multiplied by 3 or 4 as shown here, because these brain tumors are infrequent in young people." SOURCE: American Academy of Neurology E-mail this page to a friend or colleague! To print, use this version