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REM Sleep Disorder May Be Early Sign of Dementia, Parkinson’s Disease ST. PAUL, Minn -- December 29, 2008 -- People with REM sleep behaviour disorder may be at greater risk of developing dementia or Parkinson’s disease, according to a study published in the December 24 online issue of Neurology. The study involved 93 people with REM sleep behaviour disorder who had no signs of a neurodegenerative disease, such as dementia or Parkinson’s disease. The participants were followed for an average of 5 years. During that time, 26 of the people developed a neurodegenerative disease, 14 developed Parkinson’s disease, and 11 developed dementia and were diagnosed with either Alzheimer’s disease or Lewy body dementia. One person developed multiple system atrophy. The estimated 5-year risk of developing a neurodegenerative disease was 18%, with the 10-year risk at 41%, and the 12-year risk at 52%. “These results are obviously of great interest to people who have this sleep disorder and their physicians and families,” said study author Ronald B. Postuma, MD, McGill University, Montreal, Quebec. “The results may help us better understand how these neurodegenerative diseases develop. They also suggest that there may be an opportunity for protecting against the progression to disease, perhaps even preventing it before the symptoms can appear.” Dr. Postuma noted that the study involved only people with no known cause for the REM sleep behaviour disorder. The disorder can also be caused by narcolepsy or rare brainstem abnormalities. REM sleep disorder from these causes does not necessarily carry the risk of developing a neurodegenerative disease, he said. SOURCE: American Academy of Neurology E-mail this page to a friend or colleague! To print, use this version