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Patient's Self-Assessment of Cystic Fibrosis Can Help Predict Prognosis NEW YORK -- December 29, 2008 -- Adult patients with cystic fibrosis (CF) can provide important information that helps to predict their prognosis, according to a study published in the January 2009 issue of the American Journal of Respiratory and Critical Care Medicine. “We wished to see whether patients themselves had clinically relevant insight to their disease, and we found that they did,” said lead author Janice Abbott, PhD, University of Central Lancashire, Lancashire, United Kingdom. Dr. Abbott and colleagues administered 223 patients with CF the cystic fibrosis health-related quality of life questionnaire (CFQoL), then followed them for 10 years. Patient outcomes were analysed with respect to their initial self-assessment of their quality of life. After controlling for demographic factors and the severity of the disease, researchers found that several domains of patient-reported quality of life can help to predict mortality. The most important aspects were perceived physical functioning and the presence of pain. Specifically, patients reporting a lower quality of life were more likely to die sooner than those who perceived their quality of life to be higher. “The most surprising result was the importance of patient-reported pain in predicting survival in cystic-fibrosis,” said Dr. Abbott. “This work provides credibility for the use of patient-reported measures in clinical trials in CF, as it provides evidence that patient-reported outcomes can predict mortality.” SOURCE: American Thoracic Society E-mail this page to a friend or colleague! To print, use this version