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Psoriasis Independently Associated With Hyperleptinaemia CHICAGO -- December 15, 2008 -- Patients with psoriasis appear more likely to have higher levels of leptin than persons without psoriasis, according to a study published in the December issue of Archives of Dermatology. Yi-Ju Chen, MD, Taichung Veterans General Hospital and National Chung Hsing University, Taichung, Taiwan, and colleagues studied 77 patients with psoriasis and 81 individuals who were the same age and sex but did not have psoriasis. In 2006 and 2007, the researchers collected clinical characteristics of the participants, including age, sex, height, weight, any other diseases they had, and the severity of their psoriasis. Blood samples were analysed for levels of leptin. Individuals with psoriasis were more likely than controls to be obese and to have hypertension and elevated blood glucose levels or diabetes. High blood levels of leptin were found more often in females, the obese, and those with high blood pressure, metabolic syndrome, or psoriasis. "After adjustment for sex, body mass index, and conventional cardiovascular risk factors, psoriasis was independently associated in our study with hyperleptinaemia," the authors wrote. "In addition, hyperleptinaemia in psoriasis is associated with higher risk of developing metabolic syndrome. This novel finding links the chronic inflammation status of psoriasis with metabolic disturbances." The high circulating leptin levels in individuals with psoriasis may derive not only from fat tissue but also from inflammation, they continued. "Body weight loss has been reported to significantly decrease leptin levels and improve insulin sensitivity and may reduce the likelihood of developing metabolic syndrome and adverse cardiovascular diseases. Body weight loss could potentially become part of the general treatment of psoriasis, especially in patients with obesity." SOURCE: Archives of Dermatology E-mail this page to a friend or colleague! To print, use this version