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| |  DDW: Esomeprazole Provides Better Acid Control Than Lansoprazole By Mike Fillon ORLANDO, FL -- May 23, 2003 -- A higher dose (40 mg) of esomeprazole, a proton pump inhibitor (PPI), provided longer and more effective intragastric acid control than did either the 30 mg standard-dose or double-dose of lansoprazole, according to study findings. Also, the 20 mg maintenance-dose esomeprazole was shown to be more effective than the 15 mg maintenance-dose of lansoprazole and was similar to standard-dose lansoprazole. "These results show that dose escalation with lansoprazole does not result in better acid control than a standard dose of esomeprazole," said lead researcher Clive H. Wilder-Smith, MD, from the Gastrointestinal Unit and GI Physiology Laboratory in Bern, Switzerland here at Digestive Disease Week (DDW) and the 104th Annual Meeting of the American Gastroenterological Association. In the open, randomised, 6-way crossover study, 40 healthy subjects - 17 males, 23 females - with an average age of 31 years, received 20mg, 40 mg, or 80 mg of esomeprazole once daily, or 15 mg, 30 mg or 60 mg of lansoprazole once daily for 5 days, with a wash-out period of at least 13 days between treatments. Continuous 24-hour intragastric pH was recorded on day 5 of each study period. A microelectrode was placed 10 cm below the oesophageal sphincter and attached to gastrograph data logger. The same microelectrode was used during subsequent pH recordings for each subject. The percentage of time with intragastric pH (less than 4) during the 24-hour period and median 24-hour intragastric pH following dosing on day 5 were analysed using a mixed-model analysis of variance with treatment, sequence and period as fixed effects and subjects as a random effect. Consecutive doses were compared for each drug, and only subjects with assessments on the 2 treatments being compared were included in each analysis. For each dose comparison, individual responses to acid suppression were compared and the proportion of subjects that responded better to esomeprazole treatment versus lansoprazole treatment (such as longer time with pH over 4) over the 24-period was calculated. While both treatments were well tolerated:
[Study title: Comparison of Esomeprazole (20, 40, 80 mg) Versus Lansoprazole (15, 30 and 60 mg) on Intragastric pH in Healthy Subjects. Abstract 895]
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