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Low 1,25 Dihydroxy Vitamin D Linked to Mortality in Hemodialysis Patients: Presented at ASN By Maggie Schwarz PHILADELPHIA -- November 9, 2008 -- Low serum 1,25-dihydroxy (1,25-OH2) vitamin D is predictive of mortality in hemodialysis patients, researchers announced at Renal Week 2008, the American Society of Nephrology (ASN) annual meeting. Low serum 25-hydroxy (OH)2 vitamin D deficiency, however, is not related to survival. Coinvestigator Ercan Ok, MD, Ege University Medical School, Izmir, Turkey, reported results from his team's investigation here at a poster presentation on November 6. A total of 545 prevalent hemodialysis patients (mean age 58 +- 14 years, 54% male, 54 +- 45 months on dialysis, 22% diabetic) were enrolled. Serum 25-OH and 1,25-H2 vitamin D levels were measured by radioimmunoassay at baseline. Demographic, clinical, and laboratory data were recorded as well. The mean 25-OH vitamin D level was 39 +- 23 ng/mL; prevalence of 25-OH vitamin D deficiency (<30 ng/mL) was 42%. The level of 25-OH vitamin D was significantly lower in females and in diabetics and showed positive correlations with 1,25-OH2 vitamin D, albumin, hemoglobin, cholesterol, triglyceride, high-density lipoprotein, phosphate levels, and calcium-phosphate product and an inverse correlation with age and high sensitivity (hs)-C-reactive protein levels. The mean 1,25-OH2 vitamin D level was 19.2 +- 12.4 pg/mL and was significantly lower in diabetic subjects. Levels of 1,25-OH2 vitamin D were positively correlated with parathyroid hormone and inversely correlated with age. All-cause mortality was evaluated in a 2-year prospective follow-up, during which 76 subjects died (14%). Subjects who died were older and had a higher frequency of diabetes, higher hs-C-reactive protein levels, and lower levels of albumin, hemoglobin, 25-OH vitamin D, and 1,25-OH2 vitamin D. Systolic blood pressure, hs-C-reactive protein, and 1,25-OH2 vitamin D levels were independent predictors of all-cause mortality. Funding for this study was provided by Fresenius Medical Care. [Presentation title: The Impact of Activated Vitamin D Treatment on Mortality in Hemodialysis Patients. Abstract TH-PO826] E-mail this page to a friend or colleague! To print, use this version