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Alitretinoin Approved in France for Adults With Chronic Hand Eczema NEW YORK -- October 21, 2008 -- Alitretinoin (Toctino) has received national regulatory approval in France for adults with severe chronic refractory hand eczema unresponsive to potent topical corticosteroids. Pregnancy is a contraindication to alitretinoin therapy and strict pregnancy prevention measures must be in place for all women of child-bearing potential who receive alitretinoin. In clinical trials alitretinoin was well tolerated and has a safety profile overall consistent with the retinoid class. Side effects were generally dose-dependent and reversible. SOURCE: Basilea E-mail this page to a friend or colleague! To print, use this version