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MicroRNAs Used to Diagnose and Classify Renal-Cell Carcinoma: Presented at ASCP By Maggie Schwarz BALTIMORE, Md -- October 20, 2008 -- The expression profile of unique microribonucleic acids (microRNAs) may be useful in the diagnosis and prognosis of papillary renal-cell carcinoma, clear-cell renal-cell carcinoma, and chromophobe renal-cell carcinoma, according to research presented here at the American Society for Clinical Pathology (ASCP) 2008 Annual Meeting. "This is the first study to find a role of microRNA in these 3 types of renal-cell carcinoma," announced Gary Tozbikian, MD, University of Pennsylvania, Philadelphia, Pennsylvania, in a presentation on October 17. MicroRNAs modulate gene expression and are differentially expressed between a tumour and corresponding normal kidney tissue. Dr. Tozbikian and colleagues identified a distinct subset of microRNAs in the 3 categories of tumours. In papillary renal-cell carcinoma, 4 microRNAs were up-regulated and 2 down-regulated. In clear-cell renal-cell carcinoma, 7 microRNAs were up-regulated and 2 down-regulated. In chromophobe renal-cell carcinoma, 20 microRNAs were up-regulated and 3 down-regulated. Nine microRNAs were differentially expressed between chromophobe and papillary renal-cell carcinomas. Reverse-transcriptase polymerase chain reaction confirmed the results, using 6 probes for microRNA. Formalin-fixed paraffin-embedded tissue can be used to study microRNA profiles, Dr. Tozbikian explained. He added that the diagnostic utility of microRNAs merits study in the classification of renal-cell carcinoma. [Presentation title: MicroRNA Profiles of Papillary, Chromophobe, and Conventional Renal Cell Carcinomas.] E-mail this page to a friend or colleague! To print, use this version