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Modified Insulin Most Effective for Controlling Post-Meal Blood Sugar Levels ROCKVILLE, Md -- September 17, 2008 -- Premixed insulin analogues are more effective than long-acting analogues for controlling high blood sugar levels after meals in patients with type 2 diabetes, according to report published online in the Annals of Internal Medicine. The report represents a systematic review of 45 research studies and is intended to provide unbiased, evidence-based information so that clinicians and others can make the best possible treatment decisions. "While it is clear that premixed insulin analogues offer certain advantages to patients with diabetes, what is good for one patient may not be good for another," said Carolyn M. Clancy, MD, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland. The AHRQ report compared premixed insulin analogues with conventional premixed human insulin, oral diabetes drugs, and 2 other kinds of insulin analogues -- long-acting and rapid-acting analogues. The findings of the report include the following: · Long-acting insulin analogues appear to be more effective than premixed insulin analogues in lowering fasting blood sugar levels. · Premixed insulin analogues are better than long-acting analogues alone in lowering blood sugar levels after a meal with high sugar content. · Premixed insulin analogues are more effective than long-acting analogues in lowering haemoglobin A1C, which is a highly reliable indicator of chronic high blood sugar. · Premixed insulin analogues are more effective than noninsulin antidiabetic medications in lowering fasting blood sugar levels. · Premixed insulin analogues are more likely than long-acting analogues to be associated with hypoglycaemia, and are similar to premixed human insulin preparations in terms of the frequency of hypoglycaemia reported. · Premixed insulin analogues are associated with a higher frequency of hypoglycaemic events than oral antidiabetic agents are. The complete report is available at: effectivehealthcare.ahrq.gov SOURCE: Agency for Healthcare Research and Quality E-mail this page to a friend or colleague! To print, use this version