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Link Shown Between Inflammation and Heart Attack MORRIS TOWNSHIP, N.J., April 2, 1997 -- Research announced in this week's New England Journal of Medicine showing a potential link between inflammation and the subsequent development of heart attack or stroke suggests that aspirin's anti-inflammatory properties may play an important role in the drug's cardiovascular disease prevention benefits. The study, involving individuals taking aspirin on a regular basis under a physician's supervision, suggests that aspirin may provide a life-saving benefit for those with high blood levels of certain inflammation-related proteins. Publishing in this week's New England Journal of Medicine, Dr. Paul Ridker and colleagues hypothesize that it is the combination of aspirin's anti-inflammatory and anti-clotting properties that make it effective in reducing heart attack and stroke risk. The study showed that people with evidence of higher levels of proteins associated with inflammation are at greater risk for heart disease. In these people, routine aspirin use was more effective at reducing risk of first heart attack than for those with lower levels of these proteins. Thus, it appears that the anti-inflammatory effects that help make aspirin effective may contribute to its benefit in cardiovascular disease prevention as well. The authors suggest that inflammation may eventually provide a clue to assessing risk for heart disease and stroke in otherwise healthy individuals. It may also predict who will respond best to aspirin therapy. The authors cautioned that further clinical research on this issue is required. Individuals should talk to their doctor before beginning an aspirin regimen. Although in most situations, the benefits outweigh the risks, aspirin -- like all medications -- may have side effects and may not be suitable for everyone. The Consumer Care Division of Bayer Corporation is the maker of Bayer aspirin. Bayer Corporation is a research-based company with major businesses in health care and life sciences, and chemicals and imaging technologies. E-mail this page to a friend or colleague! To print, use this version