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ISICEM: Use of Anabolic Steroid Therapy in Critically Ill ICU Patients By Thomas Buckingham, MD BRUSSELS, BELGIUM -- March 19, 2003 -- Anabolic steroids show promising effects in improving nutritional status in acutely ill patients in the intensive care unit (ICU). Dr. Jill Pikul and Dr. Michael Sharpe presented data here March 18th at the 23rd International Symposium on Intensive Care and Emergency Medicine. Dr. Pikul is from the Department of Clinical Nutritional Services and Dr. Sharpe is from the Department of Anesthesia, University of Western Ontario, London, Canada, where this study was performed Acute severe illness is associated with loss of body mass, poor wound healing and decreased immune function. Aggressive nutritional therapy can improve this status, but patients still remain in negative nutritional and nitrogen balance, according to the researchers. Dr. Pikul and Dr. Sharpe studied 10 patients with severe malnutrition, who were in the ICU for more than 14 days and were tolerating enteral feeding. Patients received intramuscular nandrolone therapy weekly for 3 weeks. There was no control group in this study. Results show that eight of 10 patients attained a positive nitrogen balance and improvement in protein levels. The approach "appears to show some promise," according to Dr. Pikul, but randomised, controlled studies will be necessary to examine this issue further, she added. E-mail this page to a friend or colleague! To print, use this version