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Treating Phyllodes Tumours of the Breast With Radiation Therapy Reduces Recurrence Rates NEW YORK -- July 10, 2008 -- Patients with malignant phyllodes tumours of the breast may benefit from receiving adjuvant radiation therapy to prevent recurrence, according to a study in the July 1 issue of the Journal of Radiation Oncology*Biology*Physics. "Typically these tumours are treated well by surgery alone. However, local recurrences are not uncommon," said lead author Richard Pezner, MD, City of Hope National Medical Center, Duarte, California. Dr. Pezner and colleagues sought to determine the local recurrence rates of phyllodes tumours based on tumour size and the type of surgery performed, and whether adjuvant radiation therapy should be considered as a treatment for some patients with phyllodes tumours to reduce their local recurrence rate. The researchers reviewed records from the IMPAC National Oncology Database of 478 patients with malignant phyllodes tumours who were treated between March 1964 and August 2005. Median follow-up time was 64 months. Multivariate analysis of overall survival found several factors to be significant including advancing age with each decile after age 50, appearance of distant metastases, larger primary tumour size, and local control versus local recurrence (hazard ratio 2.5, P < .05). The authors determined that adjuvant radiation therapy should be evaluated for patients with phyllodes tumours who received lumpectomies for tumours at least 2 cm in size or a mastectomy for tumours at least 10 cm in size to reduce the risk of recurrence. SOURCE: American Society for Therapeutic Radiology and Oncology E-mail this page to a friend or colleague! To print, use this version