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Study Suggests Chemotherapy Diminishes Fertility in Breast Cancer Patients BOSTON -- May 30, 2008 -- According to a study led by investigators at the Dana-Farber Cancer Institute, Boston, Massachusetts, premenopausal breast cancer survivors treated with chemotherapy following surgery were more likely to have diminished ovarian reserve compared with women who have never had breast cancer. These findings will be presented at the American Society of Clinical Oncology (ASCO) 44th Annual Meeting, May 30 to June 3, in Chicago, Illinois. The researchers analysed markers of ovarian reserve in 20 premenopausal breast cancer patients who had been treated with adjuvant chemotherapy, who were 1 or more years out from their diagnosis, and who had no evidence of recurrence. This group was compared with a control group of 20 like-aged women without a history of the disease. The evaluation involved 5 tests conducted 2, 3, or 4 days after a menstrual cycle to assess the ovaries' physical condition, hormone levels, and a compound involved in the menstrual cycle. In 4 of the 5 tests, the breast cancer survivors had a worse ovarian reserve than did the control group. The other test showed no major difference between the 2 groups. "These findings may have important implications for women who are interested in having children after receiving chemotherapy," said Ann Partridge, MD, MPH, Dana-Farber Cancer Institute, who led the study. "Studies that track breast cancer survivors following treatment are needed to determine the predictive value of these tests for pregnancy." SOURCE: Dana-Farber Cancer Institute E-mail this page to a friend or colleague! To print, use this version