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Obstructive Sleep Apnoea a Risk Factor for Death in Stroke Patients: Presented at ATS By Marvin Ross TORONTO -- May 21, 2008 -- Stroke patients with obstructive sleep apnoea (OSA) have shorter survival times than do those who do not have OSA or who have central sleep apnoea, according to a study presented here at the 104th International Conference of the American Thoracic Society (ATS). The findings were presented on May 19 by Karl A. Franklin, MD, PhD, Professor, Department of Respiratory Medicine, University Hospital, Umea, Sweden. Dr. Franklin and colleagues conducted overnight sleep apnoea studies 15 to 31 days post-stroke on 132 of 151 patients admitted for in-hospital stroke rehabilitation between April 1, 1995 and May 1, 1997. Patients were followed for a median of 10 years. The primary outcome was death. No patient was lost to follow-up. Obstructive sleep apnoea and central sleep apnoea were both defined when the obstructive apnoea-hypopnoea index and the central apnoea-hypopnoea indices were >15. Patients with indices below 15 served as controls. Of 132 enrolled patients, 116 died during follow-up. The risk of death was higher in the 23 patients with OSA than in controls (adjusted hazard ratio [AHR], 1.76; 95% confidence interval [CI], 1.05-2.95; P = .03). This finding was independent of age, gender, body mass index, smoking status, hypertension, diabetes mellitus, atrial fibrillation, Mini Mental State Examination, and Barthel activity of daily living. There was no difference in mortality between the 28 patients with central sleep apnoea and controls (AHR, 1.07; 95% CI, 0.65-1.76; P = .053). "These findings are particularly interesting because obstructive sleep apnoea is a treatable condition," Dr. Franklin said. Evaluating patients for the presence of obstructive sleep apnoea post-stroke and treating that condition may help to increase survival for these patients, the researchers concluded. [Presentation title: Obstructive Sleep Apnea Is a Risk Factor for Death in Stroke Patients - A 10-Year Follow-Up. Abstract 3264] E-mail this page to a friend or colleague! To print, use this version