Prostate Cancer May Increase Risk of Bone Fracture
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Prostate Cancer May Increase Risk of Bone Fracture

NEW YORK -- May 14, 2008 – Study results appearing in the May 11 online edition of Bone have shown that there may be a link between prostate cancer and a higher risk of bone fracture.

Data analysis from Garvan's Dubbo Osteoporosis Epidemiology Study suggests that men with prostate cancer face a 50% higher risk of fracture, which increases to a nearly doubled risk if they are receiving treatment.

Tuan Nguyen, Associate Professor, Garvan Institute for Medical Research, Faculty of Medicine, the University of New South Wales, Sydney, Australia, and his colleagues have studied 822 men from Dubbo for nearly 20 years. These men were all aged 60 years or more in 1989 when the study began. Of the 822 men, 43 subsequently developed prostate cancer.

Twenty-two study participants received androgen deprivation therapy (ADT) and 21 did not. Compared with the men without prostate cancer, those with the disease showed a 50% increase in the risk of fracture. For those being treated with ADT, the risk increased approximately twofold.

"The results have important implications in practice for several reasons," said Dr. Nguyen. "First, most of the men who developed prostate cancer started out with a higher bone mineral density than average. Second, developing prostate cancer clearly increased their risk of fracture. Third, ADT treatment doubled their risk of fracture."

"The clear message that comes out of this study," Dr. Nguyen continued, "is that men with prostate cancer should consider seeking evaluation for osteoporosis, particularly if they are being treated with ADT."

SOURCE: Bone

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