Unregistered User If this is not your name, click here.
		Contact Us | Order Now | Journals | Bookstore | Register a colleague
	Select a ChannelAcneAIDS and HIVAllergy OtherAlzheimer'sAnaesthesiology OtherAngina Pectoris/MIAnxietyArthritis OtherAsthmaBack PainBacterial InfectionsBladder CancerBone Marrow TransplantationBreast CancerCardiology OtherCataractCell TransplantationCervical CancerCholesterol/Lipid disordersCirrhosisClinical PharmacologyColorectal CancerCongestive Heart FailureContact DermatitisContraceptionCOPDCystic FibrosisDental and Oral DisordersDepressionDermatology OtherDiabetesDialysisEating DisordersElbowEmergency MedicineEndocrinology OtherEpilepsyErectile DysfunctionFibromyalgiaGastro OtherGeneticsGenitourinary OtherGeriatricsGERD/GastritisGlaucomaH. Pylori/UlcerHaematology OtherHair LossHeadachesHepa/Biliary OtherHepatitisHipHRTHypertensionIBDImmunologyInfectious OtherInfertilityIntensive CareIrritable Bowel SyndromeKneeLeukemiasLiver CancerLung CancerLupusLymphomasMelanomaMenopauseMultiple Sclerosis Nephrology OtherNeurologic OtherNutritional / Metabolic OtherOb/Gyn OtherObesityOncology OtherOphth. OtherOphthalmic SurgeryOrgan TransplantationOrthopaedics OtherOsteoarthritisOsteoporosisOtitisOtorhino. OtherOvarian CancerPaediatricsPainPancreatic CancerParkinson'sPregnancyProstate CancerPsychiatry OtherPulmonary OtherRadiologyRenal CancerRenal FailureRespiratory InfectionsRheumatoid arthritisRheumatology OtherRhinitisSchizophreniaShoulderSleep ApnoeaSleep DisordersSpineStrokeSTDsSurgeryThyroid DisordersTransfusionTransplant Surgery OtherTraumaUrinary IncontinenceUrinary tract infectionsVaccinologyVascular DisordersViral Infections

SEARCH   News Bookstore Medline The Web Meetings & Congresses Complete Doctor's Guide    EXPLORE :    All News   All Webcasts   All Cases   All Meetings & Congresses   All Medical Resources New drugs / indications English Dictionary Medical Dictionary Thesaurus Warning | Privacy | Awards  Favourite Journals  Click here to choose your favourite journals  Favourite Sites  Click here to choose your favourite sites  Languages  Select languageEnglishFrançais

WCP: Olanzapine-Fluoxetine Better Than Olanzapine Alone For Psychotic Depression By Bruce Sylvester Special to DG News YOKOHAMA, JAPAN -- August 28, 2002 -- Patients treated with olanzapine-fluoxetine combination treatment for psychotic major depression appear to have significantly greater improvement over olanzapine alone or placebo. Researchers presented the findings at the World Conference on Psychiatry here. "This study nicely illustrates that when you use a combination of olanzapine and fluoxetine, you are able to get a synergized effect," said Sanjay Dube, MD, medical director of the Olanzapine-Fluoxetine Combination Team at Lilly Research Laboratories, Indianapolis, Indiana, United States. Researchers compared olanzapine-fluoxetine (OFC) to olanzapine or placebo in two 8-week double-blind trials with a 48-week open-label extension phase. The investigators randomised 249 subjects with psychotic depression into three treatment groups. Efficacy was evaluated with the Hamilton Anxiety and Depression - 24 (HAMD-24) scale. Response rate for the OFC group was significantly greater (56 percent) than for olanzapine (36 percent) or placebo (30 percent). Median time to response for OFC patients was significantly better (12 days) than placebo (20 days), and equal to olanzapine (12 days). In the extension phase, 71 percent of OFC responders maintained their response. Significantly more OFC partial responders (defined as 25 percent total score decrease at two weeks) reached a full endpoint response compared with olanzapine or placebo (64 percent, 35 percent, 32 percent, respectively). At endpoint, there were no significant differences in vital signs between the groups. Mean weight gain for OFC of 2.74 kg was similar to olanzapine at 3.79 (p=0.160) and greater than for placebo at .39 kg. (p=001). There were no statistically significant differences between treatment groups on any scale of extrapyramidal symptoms "With OFC therapy we have a safe combination with a good clinical effect," Dr. Dube added. E-mail this page to a friend or colleague! To print, use this version