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Desvenlafaxine Improves Pain, Well Being, and Functioning in Depressed Patients: Presented at CPA By Alison Palkhivala MONTREAL, CANADA -- November 20, 2007 -- Desvenlafaxine (Pristiq(R)) improves measures of pain, well-being, and functioning, according to a study presented in here at the 57th Annual Conference of the Canadian Psychiatric Association (CPA). "The idea was to look at males and females treated for depression to see how much treatment impacts functional well-being, social impairments, work impairments, family impairments, and pain," said author Claudio N. Soares, MD, PhD, Associate Professor of Psychiatry, director, Women's Clinic, McMaster University, Hamilton, Ontario, Canada. The investigators conducted a pooled analysis of six double-blind, placebo-controlled trials involving nearly 2,000 patients with major depressive disorder who were randomised to a 100- to 400-mg daily dose of desvenlafaxine or placebo for 8 weeks. Outcome measures were the Sheehan Disability Scale (SDS), World Health Organization Well-Being Index (WHO-5), and the Visual Analog Scale of Pain Intensity (VAS-PI). Patients were assessed using these measures at baseline, 2 weeks, 4 weeks, and 8 weeks. After 8 weeks of therapy, patients experienced significant improvements on all three measures compared with placebo (P <.001 in all three cases), Dr. Soares said during the poster presentation on November 16. Treatment with desvenlafaxine decreased social, family, and work impairments. It also improved emotional well-being and decreased pain in men and women," he said in an interview. "There was always a trend that it worked better in females than males, although this never reached statistical significance. This could be due to sample size." Interestingly, women over the age of 55 years had higher baseline pain scores than men or younger women. "Further studies are needed to determine potential contributing factors for increasing painful physical symptoms in women transitioning to menopause or postmenopause," the authors wrote in their poster. The pooled analysis was conducted in collaboration with Wyeth Research, which manufacturers Pristiq. [Presentation title: Efficacy of Desvenlafaxine Succinate for Improving the Pain and Impairment in Functioning and Well Being Associated With Depression in Younger, Midlife, and Older Women and Men. Poster P18] E-mail this page to a friend or colleague! To print, use this version