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ICPD: Long-Term Cabergoline Practical In Elderly With Parkinson’s Disease By Richard Robinson Special to DG News HELSINKI, FINLAND -- July 30, 2001 -- The long-acting dopamine agonist cabergoline can be used even in elderly Parkinson’s disease patients. The findings were presented at the 14th International Congress on Parkinson’s Disease in Helsinki, July 27-August 1, 2001. "Dopamine agonists are often avoided in the elderly with Parkinson’s disease, to avoid side effects such as psychosis," said K. Ray Chaudhauri, of King’s College Hospital, London. However, he noted, cabergoline may have the potential to avoid some of these effects because of its extremely long half-life of 65 hours. With the resulting more steady plasma levels, he hypothesized, intolerable side effects might be minimized. To test this, Dr. Chaudhauri and colleagues at two other centers enrolled 299 patients of different ages and disease severity who had begun cabergoline therapy, and followed them for two years. Tolerability was defined as at least six months of cabergoline use without side effects requiring discontinuation. Contrary to the usual expectations, patients at all ages were essentially equally tolerant of the agonist treatment, with tolerability seen in 85 percent of patients under 65, 80 percent of patients 65-74, and 83 percent of patients 75 and above. Fifty-four patients discontinued during the study, including seven for lack of efficacy and seven for hallucinations. Dr. Chaudhauri noted that the slow titration of cabergoline, over several months, probably contributed to the success of the treatment and minimization of side effects. The study presented updated data from the study titled, "The tolerability and efficacy of sustained dopaminergic therapy, using cabergoline mono or adjunctive therapy in 202 elderly and young PD patients: A two-year observational study", supported by industry. E-mail this page to a friend or colleague! To print, use this version