Unregistered User If this is not your name, click here.
		Contact Us | Order Now | Journals | Bookstore | Register a colleague
	Select a ChannelAcneAIDS and HIVAllergy OtherAlzheimer'sAnaesthesiology OtherAngina Pectoris/MIAnxietyArthritis OtherAsthmaBack PainBacterial InfectionsBladder CancerBone Marrow TransplantationBreast CancerCardiology OtherCataractCell TransplantationCervical CancerCholesterol/Lipid disordersCirrhosisClinical PharmacologyColorectal CancerCongestive Heart FailureContact DermatitisContraceptionCOPDCystic FibrosisDental and Oral DisordersDepressionDermatology OtherDiabetesDialysisEating DisordersElbowEmergency MedicineEndocrinology OtherEpilepsyErectile DysfunctionFibromyalgiaGastro OtherGeneticsGenitourinary OtherGeriatricsGERD/GastritisGlaucomaH. Pylori/UlcerHaematology OtherHair LossHeadachesHepa/Biliary OtherHepatitisHipHRTHypertensionIBDImmunologyInfectious OtherInfertilityIntensive CareIrritable Bowel SyndromeKneeLeukemiasLiver CancerLung CancerLupusLymphomasMelanomaMenopauseMultiple Sclerosis Nephrology OtherNeurologic OtherNutritional / Metabolic OtherOb/Gyn OtherObesityOncology OtherOphth. OtherOphthalmic SurgeryOrgan TransplantationOrthopaedics OtherOsteoarthritisOsteoporosisOtitisOtorhino. OtherOvarian CancerPaediatricsPainPancreatic CancerParkinson'sPregnancyProstate CancerPsychiatry OtherPulmonary OtherRadiologyRenal CancerRenal FailureRespiratory InfectionsRheumatoid arthritisRheumatology OtherRhinitisSchizophreniaShoulderSleep ApnoeaSleep DisordersSpineStrokeSTDsSurgeryThyroid DisordersTransfusionTransplant Surgery OtherTraumaUrinary IncontinenceUrinary tract infectionsVaccinologyVascular DisordersViral Infections

SEARCH   News Bookstore Medline The Web Meetings & Congresses Complete Doctor's Guide    EXPLORE :    All News   All Webcasts   All Cases   All Meetings & Congresses   All Medical Resources New drugs / indications English Dictionary Medical Dictionary Thesaurus Warning | Privacy | Awards  Favourite Journals  Click here to choose your favourite journals  Favourite Sites  Click here to choose your favourite sites  Languages  Select languageEnglishFrançais

ICPD: Pergolide Effective In Restless Legs Syndrome By Richard Robinson Special to DG News HELSINKI, FINLAND -- July 30, 2001 -- The dopamine agonist pergolide appears to effectively treats the symptoms of restless legs syndrome (RLS). Dr. Claudia Trenkwalder of the University of Goettingen, in Goettingen, Germany, presented the results of a one-year, double-blind study at the 14th International Congress on Parkinson’s Disease in Helsinki, July 27-August 1, 2001. Dr. Trenkwalder and colleagues enrolled 100 patients with RLS, who received either placebo or 0.40 mg pergolide at bedtime. After six weeks, pergolide-treated patients achieved improvements in subjective RLS severity and significant decreases in nighttime arousal, as determined by polysomnography. "The treated patients fell to a level that was almost equivalent to the normal level everyone experiences during sleep," Dr. Trenkwalder said, noting that the benefit continued during the day. Patients who responded to their treatment continued that treatment while maintaining the blind, while non-responders from either arm began open-label pergolide. "It is interesting," Dr. Trenkwalder noted, "that a small fraction of patients continued on placebo for a year and continued to report benefit." These patients did not have improved polysomnography, however, while all pergolide-treated patients did. At the end of the year, 30 of 46 patients remained on blinded pergolide at the same dose, and maintained normalized arousal index. Sleep latency in pergolide-treated patients also fell, by approximately 50 percent. "This is the first study to demonstrate long-term efficacy and safety of pergolide in RLS," concluded Dr. Trenkwalder. Restless legs syndrome is a common neurological condition causing discomfort in, and an urge to move the legs. Symptoms are worst at night, but continue throughout the day. The research, titled, "Results of a long-term controlled multicenter trial of pergolide in the treatment of restless legs syndrome", was supported by Eli Lilly E-mail this page to a friend or colleague! To print, use this version