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ICC: Cefixime Safe For Children With Relapsing Urinary Tract Infection By Pamela A Hunter Special to DG News AMSTERDAM, THE NETHERLANDS -- July 3, 2001 -- Young children with relapsing urinary tract infections (UTIs) are vulnerable to kidney damage and kidney function needs to be monitored carefully if any antibiotic treatment is given. Dr V. Fanos and colleagues (University of Verona and Laboratory Department, Padua, Italy) presented data at the 22nd International Congress of Chemotherapy, Amsterdam, July 1st-3rd, 2001 showing that the broad spectrum cephalosporin cefixime is safe to administer prophylactically to young children with recurrent UTI. They studied 10 males and 10 females aged between one month and four years all of whom had a history of at least two episodes of UTI in the previous two months. The predominant organisms (78.2 percent) causing the infections were Escherichia coli and Proteus mirabilis. The authors used two assays to monitor kidney function; detection of urinary levels of N-acetyl-beta-D-glucosaminidase (NAG), using a colorimetric method and urinary levels of creatinine, using the Jaffe kinetic method. These methods provide a sensitive measure of any potential damage to the kidney. Blood urea nitrogen (BUN) determinations and other kidney function tests were also made at intervals. Urine samples were collected at weekly intervals for NAG and creatinine measurements. The children received a 4 mg/kg dose of cefixime at bedtime for a period of one to two months. The urinary NAG levels were 0.508 (+/- 0.307) with a range of 0.05-1.17. These values were well within the quoted normal range for paediatric patients (upper limit of normal range 1 U/mmol) with only one patient having a value (1.17) just outside the normal range. All other kidney function tests were normal, including BUN and serum and urinary creatinine. No infections occurred during the period of treatment. Cefixime proved to be well tolerated and effective as a prophylactic agent in these very young children with recurrent UTI. E-mail this page to a friend or colleague! To print, use this version