If this is not your name, click here.
| | If this is not your name, click here. | | |
| | Contact Us | Order Now | Journals | Bookstore | Register a colleague | | |
| |  Various Lipid Subfractions Associated With Carotid Intimal Medial Thickness in Diabetic Asian Indians: Presented at DALM By Crina Frincu-Mallos, PhD NEW YORK, N.Y. -- October 16, 2007 -- Abnormal lipid levels are associated with higher carotid intimal medial thickness in a diabetic Asian Indian population, researchers reported here at the XVI International Symposium on Drugs Affecting Lipid Metabolism (DALM). "The aim of the study was to determine the association of various lipid abnormalities with carotid intimal medial thickness (IMT) in Asian Indians," said Brijendra Kumar Srivastava, MD, Diabetologist, and colleagues from Madras Diabetes Research Foundation, Chennai, India in a poster presentation on October 5. For this study, the researchers selected a total of 2,350 subjects from phase 3 of the Chennai Urban Rural Epidemiology Study (CURES), a population-based study that analysed the characteristics of 26,001 subjects from Chennai, the fourth largest city in India, population 4,343,645. In CURES, subjects were screened and divided into three groups: those diagnosed with diabetes according to World Health Organisation criteria went into phase 3, while those diagnosed with diabetes by ADA criteria and with diabetes-related complications entered phase 1 and phase 2, respectively. All subjects had their fasting plasma glucose, serum cholesterol, triglycerides, and HDL-C levels measured. Carotid IMT was measured noninvasively by B-mode high-resolution colour Doppler ultrasound. Looking at the mean IMT values in relation to hyperlipidaemia, normal lipid levels were associated with lower IMT, said the researchers. For example, for optimal low-density lipoprotein cholesterol (LDL-C) levels (<100 mg/dL), the associated IMT value was 0.67 +- 0.14 mm, while for very high LDL-C levels (>=190 mg/dL), the mean IMT value was 0.78 +- 0.10 mm (P <.001). In addition, linear regression analysis using IMT as an independent variable indicated a relevant correlation between IMT and LDL-C (B:0.0002, P =.016), non-high-density lipoprotein cholesterol (HDL-C, B:0.00021, P =.046), as well as the ratio of triglycerides to HDL-C (B:0.0093, P =.0061). However, there was no significant association between HDL-C and IMT (B:-0.00078, P =.0501). Speculating on the clinical implications of these results, the investigators stressed the importance of keeping the non-HDL-C and LDL-C in the near-normal range, to minimize the risk of atherosclerosis and coronary artery disease.
[Presentation title: Association of Various Lipid Abnormalities With Carotid Intima Medial Thickness (IMT) in Asian Indians "The Chennai Urban Rural Epidemiology Study". Abstract 210]
|
