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DG DISPATCH - ISH: Droloxifene Lowers Blood Pressure In Healthy Postmenopausal Women By Lara Pullen Special to DG News CHICAGO, IL -- August 23, 2000 -- Droloxifene is the first selective estrogen receptor modulator (SERM) shown to lower blood pressure in healthy postmenopausal women. At the 18th Scientific Meeting of the International Society of Hypertension (ISH), Dr. K. Bridget Brosnihan of the Wake Forest University School of Medicine, Winston-Salem, NC, presented the results of a study which compared the effects on blood pressure of conjugated equine estrogen and the tamoxifen analogue, droloxifene. The study included 24 healthy postmenopausal women between the ages of 50 and 65 years. The women had fasting low-density lipopolysaccharide levels of less than 200 mg/dL and triglyceride levels of less than 400 mg/dL. The women had an average systolic blood pressure (SBP) of 133 and an average diastolic blood pressure (DBP) of 72. While conjugated equine estrogen had no effect on blood pressure levels, droloxifene significantly reduced blood pressure levels (5 percent decrease for SBP and 8 percent decrease for DBP). Both estrogen and droloxifene increased the levels of plasma angiotensin II, although neither had a significant effect on angiotensin I. Dr. Brosnihan noted that these results were seen in healthy women with no cardiovascular risk and the research needs to be expanded to include a larger group of women with varying degrees of cardiovascular risk. E-mail this page to a friend or colleague! To print, use this version