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| |  Antibiotics Have Limited Effect On Children With Acute Otitis Media ROCKVILLE, MD -- August 9, 2000 -- Almost two-thirds of children with uncomplicated acute otitis media (AOM) recover from pain and fever within 24 hours of diagnosis without treatment with antibiotics, and over 80 percent recover within one to seven days. When treated with antibiotics, up to 93 percent of children will recover during the first week. These are the findings of an analysis of clinical studies conducted on children four weeks to 18 years of age from 1964 through 1998. The analysis was conducted by the Southern California/RAND Evidence-based Practice Center (EPC) sponsored by the Agency for Healthcare Research and Quality (AHRQ). The EPC found no evidence to conclude that children with AOM treated with amoxicillin fared any differently from those treated with more expensive antibiotics such as cefaclor, cefixime, azithromycin, or clarithromycin. Furthermore, amoxicillin caused fewer side effects. The EPC also found no evidence that short-duration (five days or less) versus long-duration therapy (seven - 10 days) made a difference in the clinical outcome for children over two years of age. "Acute otitis media was chosen as an EPC topic because the lack of a standard definition and diagnosis criteria has created a great deal of uncertainty about whether, and which, antibiotics are an effective treatment," said Lisa Simpson, M.B., B.Ch., M.P.H., AHRQ deputy director. "This EPC report gives clinicians and policy makers information to address the controversy over the use of antibiotics in treating children with acute otitis media." AOM is one of the most common diagnoses in children. The EPC estimates that over 5 million episodes of AOM occur each year at a cost of approximately US$3 billion. It is routine to use antibiotics for AOM in the United States, whereas in other countries, such as the Netherlands, the standard practice is to use "watchful waiting" for one to two days after the onset of an ear infection in children over two years of age, treating only if the infection fails to improve during that time. Although the EPC did not evaluate bacterial resistance to antibiotics, it has been reported that the rate of bacterial resistance in the Netherlands is about 1 percent, compared with the U.S. average of around 25 percent. The EPC suggests that future research examine the efficacy of antibiotics versus "watchful waiting" and a possible link to bacterial resistance. The EPC also pointed out other weaknesses and gaps in the literature that should be addressed in future research. These include the need for standard definitions of AOM and its outcomes and standard criteria for its diagnosis. In addition, the EPC encouraged rigorous study of factors that may influence AOM outcomes such as age and being prone to AOM.
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